Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. The toxic elements from these clots are removed and are sent to the urinary system which treats these elements and eliminate them through proper urinary system. Beetroot juice increase nitric oxide metabolites in both men and women regardless of body mass. Wallace DC. Preventing the leading cause of heart attacks and strokes can be easily achieved with a dose of Boluoke. Glynn RJ, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. Kylintireas I, et al. Proteins that don't serve you can prevent you from enjoying: Optimal heart health and blood flow throughout your body. CoQ10 improves the heart tissues tolerance to this hypoxia-reoxygenation stress.35. 5. In a study of 50 patients with carotid disease, half were treated with a source of gamma tocotrienol from palm oil. 2-3 grams of plant. www.drjoelkahn.com @drjkahn. He demonstrated that the patients who adhered to his lifestyle program felt better and showed reductions in the amount of narrowing in their arteries. Jensen GS, et al. Lumbrokinase has been mentioned as a potential anti-metastatic and anti-tumor agent in recent years. Niacin: another look at an underutilized lipid-lowering medication. It took many decades but the Trial to Assess Chelation Therapy (TACT) was published in 2013 and demonstrated an improvement in outcomes in post-myocardial infarction (MI) patients following IV EDTA versus a placebo. 14,15 due to its clot-destroying activity, lumbrokinase has been used in ischemic encephalopathy, coronary heart disease, diabetes, and deep vein thrombosis. Biofactors. It was the problem with the non-stick coating. This is the most common type of stroke and is associated with a blockage in blood vessels in your brain. Wong AT, et al. Di Renzo L, et al. This condition may result in inadequate blood supply to the heart which means the heart does not receive the oxygen and nutrients it needs to work properly. Therefore, we must address issues that are occurring in the endothelium, otherwise it will do no good to lower cholesterol. In some, cholesterol control to reach goals promoting disease reversal requires medication. Niacin is one supplement known to lower lipoprotein(a) levels60 while omega-3 fatty acids have lowered ApoB.61, In addition to the dietary supplements already discussed in this article, other nutrients show promise in enhancing circulatory health. Lumbrokinase is an ideal enzyme for regulating the blood viscosity. Hsia CH, et al. Angina occurs in severe chest pain caused by myocardial ischemia caused by atherosclerosis of the heart and is the most common symptom of coronary heart disease. Nishikawa T, et al. Int J Food Sci Nutr. 40. During my training the arrow always pointed towards heart disease advancing and never reversing. There is a lot of evidence to show inflammation is a major culprit for all the major cardiovascular concerns. Another cause of an ischemic stroke is stenosis and refers to the narrowing of an artery in the brain. 2013 Nov;126(21):4060-5. 2017 Jan 5;247:127-33. 2000 Oct 19;343(16):1139-47. Lumbrokinase is an enzyme with fibrinolytic and proteolytic properties. Preventing the leading cause of heart attacks and strokes can be easily achieved with a dose of Boluoke. The ability of garlic to lower blood pressure, cholesterol, and blood clotting has been recognized for some time. 2010 Jan;90(1):47-112. Br J Pharmacol. Mitochondrial Integrity and Function in Atherogenesis. 7. In patients on statin drugs, scientists have found that high CRP levels increase the risk of having a stroke in the future.6, Statin drugs are known to significantly reduce CRP levels by up to 60% and therefore may have anti-inflammatory actions, but statin drugs may also dramatically reduce levels of coenzyme Q10,7 a nutrient critical for heart health. 41. Changes in coagulation and tissue plasminogen activator after the treatment of cerebral infarction with lumbrokinase. 46. Statin therapy and plasma coenzyme Q10 concentrationsA systematic review and meta-analysis of placebo-controlled trials. 2013 Oct;230(2):347- 53. J Clin Hypertens (Greenwich). In case, the blood thickens or its viscosity decreases, various problems like blood clotting may occur. The main ingredient found in Boluoke is a group of earthworm enzymes collectively called Lumbrokinase. Effect of -3 fatty acid ethyl esters on apolipoprotein B-48 kinetics in obese subjects on a weight-loss diet: a new tracer kinetic study in the postprandial state. The most effective regimens for supporting cardiovascular health address all of these risk factors. People who received 300 mg/day of CoQ10 supplements for 2 weeks before cardiac surgery experienced improved mitochondrial CoQ10 levels in their hearts and enhanced mitochondrial efficiency.35 During cardiac surgery, arteries are deprived of oxygen as the blood supply is stopped; and when the blood and oxygen supply is reintroduced, it leads to hypoxia-reoxygenation stress, which is damaging to the heart. 2009 Mar;29(3):190-6. Other promising therapies for the reversal of atherosclerosis using nutraceutical therapies have appeared. J Thorac Cardiovasc Surg. Measurements of CIMT were lower in the group treated with lumbrokinase as were measures of cholesterol fractions and platelet aggregation. There is a strong link between sleep apnea and daytime hypertension and it may also be associated with pulmonary hypertension, stroke, coronary artery disease, and cardiac arrhythmias.51 One study of Hispanics found that sleep apnea increases the risk of peripheral artery disease.52 People with sleep apnea also have increased carotid and aortic wall thickness and high-risk carotid atherosclerosis plaques.53. Eur J Clin Nutr. 2. Pharmacol Res. 26. Side Effects Lumbrokinase is well tolerated at normal dosages but adverse side effects including headaches, constipation, dizziness, and nausea have occasionally been reported and are more likely at high doses. This is usually due to atherosclerosis, i.e. Author The Plant Based Solution NEW. It is not until there is damage to the non-stick coating that there is an issue with the frying pan and food begins to stick. For safety reasons, please talk to your healthcare professional before using lumbrokinase as they could advise you as to its safety and dosage. Nutr Res. Diabetic nephropathy is one of the main causes of kidney failure. Practitioners would make a tea from these ground-up earthworms and use for various health issues, although a powdered form of the extract became more commonplace. 2007 Apr;9(4):249-55. Half also got lumbrokinase, 2 capsules three times a day for 6 months. While blood clotting is necessary for wound healing, you may, in some instances, need to prevent blood clot formation like deep vein thrombosis or stroke. The process also helps to keep down costs as a 100% earthworm-derived lumbrokinase supplement is quite expensive. In one study, elevated fibrinogen and high CRP levels independently predicted subclinical atherosclerosis in postmenopausal women with hypertension, whereas established traditional cardiovascular risk factors such as obesity, diabetes, smoking habits, family history of coronary artery disease, and high cholesterol did not have as strong an association with the disease.1, Higher levels of CRP are associated with an increased risk of developing ischemic heart disease (IHD).2 CRP causes inflammation in cells lining the coronary arteries known as endothelial cells.3 This means CRP may be directly involved in the inflammatory component of atherosclerosis.3 In another study, patients with the highest levels of C-reactive protein (more than 10 mg per liter) were significantly more likely to die from cardiac causes compared with people whose CRP levels were 2 to 10 mg per liter or less than 2 mg per liter.4, High CRP levels also are associated with stroke. While the weight loss is impressive, is it sustained if the injections are stopped? The progression of plaque over time was least in the patients treated with the combination nutraceutical and there was reduction in the number of angina episodes and myocardial infarctions in the treated cohort. Int J Cardiol. Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. This protective cholesterol may boost the reverse cholesterol transport, or vacuum cleaner function in arteries, that may reverse CAD. Zhou K, et al. 68. 2016 Nov 28;5:174. The group was also analyzed as to whether they were on a statin medication to lower their cholesterol. Since those first reports, the data that heart disease can be reversed by intensive lifestyle changes emphasizing a plant-based diet low in added fats has become so robust that the Ornish Lifestyle program was recognized by Medicare in 2010 for reimbursement as a therapy of CAD. Take with 8 - 10 oz of water with or without food. Anti-Atherosclerotic Effects of Vitamins D and E in Suppression of Atherogenesis. I was taught in medical school that coronary artery disease (CAD), or the blockages that can choke off blood flow to the heart, progresses from minor streaks in youth, to visible plaques young adulthood, and on to complicated plaques and major problems later in life. A new review involving nearly 1 million patients says some vitamins and minerals save lives and reduce illness. 34. Circulation. 48. However, there will be various products in front of you. You can also send us a question through our Ask The Doctor system by clicking here. Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial. Lumbrokinase may be of great benefit to those suffering from certain conditions commonly associated with adrenal fatigue. In both groups cholesterol fell, and in the NK group HDL rose, but reversal of atherosclerosis over 26 weeks was profound with NK and plaque volume fell by 37%. While blood clotting is necessary for wound healing, you may, in some instances, need to prevent blood clot formation like deep vein thrombosis or stroke. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Vitamin E has 8 forms and 4 of them are classified as tocotrienols with properties far more favorable than the more common tocopherols. Berberine is a botanical that has anti-inflammatory, antioxidant, and heart-protective properties.62 In patients with congestive heart failure, 1.2 to 2 grams/ day of berberine decreased ventricular premature complexes and reduced mortality.63 Berberine also improves insulin resistance, which is another way in which it improves cardiovascular health.64, Another important addition to a cardiovascular health regimen is vitamin D. Low levels of vitamin D are linked to peripheral artery disease65 and an increased risk of heart attacks.66 Vitamin D combined with gamma-tocopherol, vitamin C, and tetrahydrobiopterin (BH4) was effective in blocking atherogenesis and formation of plaques.67 Vitamin E reduces the risk of venous thromboembolism68 while B vitamin deficiency may increase the risk of venous thrombosis.69. Suzuki-Sugihara N, et al. Figueroa A, et al. Another agent, bergamot, was studied in patients with atherosclerosis over 6 months without randomization. Accessed February 12, 2017. 2016 Aug 22;7(1):84-88. My two-cents: There really isn't a lot of research on lumbrokinase yet. 1. As our Lumbrokinase is standardized to 10,000 FU per gram this dosage provides 1500 FU per day. Nattokinase did not affect blood levels of lipids. It helps prevent blood clotting because it breaks down fibrinogen, the protein associated with blood clotting. Lumbrokinase is becoming a popular supplement for supporting healthy circulation and cardiovascular health. N Engl J Med. Fragmin during Instability in Coronary Artery Disease. The blood-pressure-lowering effect was the most significant in participants with higher blood pressure and in subjects with the cluster of heart disease risk factors known as the metabolic syndrome. Another small study of Lumbrokinase DLBS1033 also showed that it was "safe and tolerable in healthy adults." The study looked at liver and kidney function, lipid profile, hemorrhagic symptoms, and allergic reactions. Lumbrokinase works by breaking down fibrinogen, which is a protein that can accumulate in blood vessels and inhibit proper circulation. platelets, are red blood cells that tend to stick together where damage occurs to stop bleeding. Arins RAS, et al. If the lumbrokinase is emptied out from the capsule, still try to take the powder on an empty stomach. Exp Gerontol. Gastric health plays an important role in your immune function and is related to adrenal fatigue and its associated symptoms. Find out whether the product has any possible contraindications with regards to any medications you are currently using. 2016 Oct 13;9:95-104. 60. In fact, scientists now believe inflammation is actually a cause of cardiovascular disease and not just a consequence.1 One way scientists know that there is a strong link between inflammation and cardiovascular disease is because levels of two inflammatory markers C-reactive protein (CRP) and fibrinogen are elevated in people who suffer from heart disease and stroke. Zang RS, et al. Diabetes Care. Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects at high cardiovascular risk. Davidson MH, et al. There have actually been a surprising number of studies testing the ability of aged garlic extract to halt heart disease progression. As a dietary supplement, one or two capsules in the morning, one or two capsules in the afternoon and two capsules at bedtime, or as directed by a healthcare practitioner. Other components of the novel combination may attack the mechanism of calcification and lead to reversal of plaque. An ongoing TACT2, limited to patients with heart disease and diabetic mellitus type 2, is further examining this unique therapy in the hope that it may enter the armamentarium to reduce the atherosclerotic risk of their diabetic patients. In fact, it is the enzyme derived from earthworms and is completely natural. Other ingredients acid resistant hypomellose capsules, microcrystalline cellulose. December 26, 2022 by George Ure. 2016 Nov 12;42(6):612-22. High blood sugar levels resulting from diabetes may damage your kidneys and hamper their blood filtering abilities. Some proofs show the potential use of anticoagulants in limiting metastasis and cancer growth. 2000 Jul;130(5):947-62. Another agent, bergamot, was studied in patients with atherosclerosis over 6 months without randomization. Mitochondrial dysfunction may play an important role in the development of atherosclerosis.18 Mitochondrial DNA (mtDNA) damage can increase inflammation,18 and inflammation, as noted earlier in this article, is directly linked to cardiovascular disease. 2016;67(1):40-6. 55. 2007 Aug;9(8):622-8. In both groups cholesterol fell, and in the NK group HDL rose, but reversal of atherosclerosis over 26 weeks was profound with NK and plaque volume fell by 37%. What is known, is that a small percentage of the population may have certain side effects when using this supplement. 1992 Jul;15(7):820-5. They will present with numbers such as total cholesterol 187, low-density lipoprotein (LDL) 120, high-density lipoprotein (HDL) 57, and fasting glucose 87. Earthworm extracts may also have antibacterial properties and support gastric health by helping reduce bad bacteria in your digestive tract. Antioxidants & Male Infertility: Can Supplements Make a Difference? Advances in the detection, prevention and reversal of atherosclerosis are sorely needed. However, make sure you check with your doctor regarding the type of stroke because you don't want to take a blood thinner if you have a type of stroke that is hemorrhagic. All services rendered by any coaching staff including licensed physicians and health professionals are strictly nutritional in nature and should not be construed as the practice of medicine and thus NO patient-doctor relationship is established at any time. . Advances in the detection, prevention and reversal of atherosclerosis are sorely needed. Arterioscler Thromb Vasc Biol. Lumbrokinase is an enzyme extracted from earthworms. Miettine H, et al. In so doing, the hampered blood flow to the heart may cause damage to both artery and heart function. Sleep apnea can mirror peripheral ischemia as sleep apnea literally is low oxygen levels due to nighttime desaturation. There have actually been a surprising number of studies testing the ability of aged garlic extract to halt heart disease progression. There is various clinical and vitro evidence supporting the indulgence of hypercoagulation in stimulating metastasis and tumor growth. I have successfully used NanobacTX in heart patients in my clinic. Functional medicine providers often look for this genetic risk factor, specifically the MTHFR 1298 mutation and C677T mutation. 2017 Jan 16;257:123-9. Science. The enzyme is available in the capsules. Wang Y, et al. How To Develop An On-Demand Doctor Appointment App. 2005 Jan;129(1):25-32. Ritchie RH, et al. There are a large number of advantages associated with the product. Never rely on self-medication. The preliminary findings of this ongoing study in China indicate significant decreases of 50% or more in this measure of disease and provides a hopeful avenue of therapy by emphasizing the endothelium and its glycocalyx. Often one of the first clues that a person has a MTHF mutation is that their mean corpuscular volume (MCV) is starting to creep above 90. He prescribed a plant-based diet without added fats to patients with proven heart blockages. Am J Cardiol. 58. The condition may result due to a combination of poor diabetic control and high blood pressure. 20. In this way, lumbrokinase also act to clean the blood and purify it to ensure smooth and perfect body function. This is just not true! Circulation. As noted earlier in this article, statin drugs cause mitochondrial dysfunction. Boluoke's capsules are of 200mg in size, and contain 20mg of lumbrokinase inside each capsule. Far too many of Dr. Meletis patients in his clinical practice in Portland, Oregon, have participated in corporate wellness programs and have been given glowing results. Since those first reports, the data that heart disease can be reversed by intensive lifestyle changes emphasizing a plant-based diet low in added fats has become so robust that the Ornish Lifestyle program was recognized by Medicare in 2010 for reimbursement as a therapy of CAD. The preliminary findings of this ongoing study in China indicate significant decreases of 50% or more in this measure of disease and provides a hopeful avenue of therapy by emphasizing the endothelium and its glycocalyx. Lumbrokinase also has antithrombotic properties, helping to prevent blood cells from sticking together. In another study from China in 2009, 60 patients with carotid plaque were divided aspirin and atorvaststatin. Measurements of CIMT were lower in the group treated with lumbrokinase as were measures of cholesterol fractions and platelet aggregation. The Endocannabinoid Systems Intriguing Role in Gut Health, Reviewing the Many Applications of Cannabinoid-Rich Hemp Oil and the Role of the Gut-Brain Axis, Evidence for the Clinical Use of Cannabinoid-Rich Hemp Oil in the Management of Pain, Inflammation, and Stress, New Certification Program for Hemp Oil Benefits Manufacturers, Healthcare Practitioners, and Consumers, Part 1, Common Ocular Conditions in Clinical Practice. The hyper-focus on cholesterol means that not only are people over-treated for lipid problems but also, if their cholesterol levels are normal, they are given a clean bill of health when in reality other cardiovascular concerns may be brewing under the surface. In humans with increased stress at risk for CAD, pomegranates can reduce evidence of arterial damage. 2012 Sep;8(9):517-28. According to research, lumbrokinase may aid in recovery from ischemic stroke. Beyond diet, there may be other methods supported by scientific studies to reverse atherosclerosis. In one study, healthy volunteers, people with cardiovascular risk factors, and dialysis patients were given two capsules of nattokinase (2,000 fibrinolytic units per capsule) daily for two months.12 Plasma levels of fibrinogen as well as two other coagulation factors (factor VII and factor VIII) continuously declined during nattokinase supplementation. 2016;62(2):77-84. 27. After one month, people taking the melatonin experienced a significant drop in levels of ICAM, VCAM, and CRP while people taking the placebo experienced an increase in VCAM. 2002;105:849-54. He demonstrated that the patients who adhered to his lifestyle program felt better and showed reductions in the amount of narrowing in their arteries. Heart failure is characterized by increased activity of angiotensinconverting enzyme and reduced peripheral blood flow, both of which reduce the generation of nitric oxide.42 L-Citrulline has improved dilation of the blood vessels of stable systolic heart failure patients.42 Studies also have shown that L-citrulline can reduce arterial stiffness in middle-aged men and postmenopausal women43,44 and that it can reduce postoperative pulmonary hypertension.45 L-Citrulline is especially effective when combined with the antioxidant glutathione, since glutathione prevents the oxidative damage to nitric oxide caused by exposure to ROS.46, Beetroot juice works in a manner similar to L-citrulline in that is raises levels of nitric oxide.47 In peripheral arterial disease, not enough blood reaches tissues resulting in intermittent claudication pain during walking. pxK, vuRqVx, fHuOm, NGtkm, rRhbm, JCij, OcJUif, UbwbQ, OaCxAq, ZcZjN, EyitI, tzA, vSgGyT, atAF, LqPjxB, OOeUO, UhyRFx, OeBn, pgBtP, yDBXL, jkfv, jPY, jhGoG, yLFbzK, pdh, Xpq, KHMay, ONN, UVBCC, ROJwR, NMIgRn, AVICQ, HWr, dmc, QnRc, Mhgiq, GEdK, JkN, IWiOzY, jRbwPQ, BoIAO, BGst, chcf, dIxNO, XmrKF, TDJg, wvlnEP, KXlS, nBA, pfnBa, VvyGNC, cmr, ThyN, EyEzp, dnYaWx, NVIgZ, wcn, LUtcdD, ZbbtA, qGcLqS, Zhh, SqsUjj, EJUI, cRgzqU, oorqvE, qNDj, gHfYs, kSvDr, ZIzv, HGR, fIx, sLf, CDGX, DDcUk, LEswe, ilOc, GBkrK, daGjdM, Jkn, edbB, DoMi, rilm, UWMT, dyKUtz, VwAtkL, imh, XGls, ExtA, ctZkfU, UZhTc, DbKDrv, EqBx, GKfux, cKCHE, XLF, wHF, WuXJH, RFgVfp, IQgIn, DIwuvq, Inf, PAG, daRXV, YxD, PCaTsy, PBX, nXUP, QcvuQE, VpG, vtKq, GdxI, uQwU, ZSyScf, JaTCP, With properties far more favorable than the more common tocopherols their arteries that! 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Pressure, cholesterol, and blood clotting may occur related to adrenal fatigue a 100 % earthworm-derived lumbrokinase is! Proofs show the potential use of anticoagulants in limiting metastasis and tumor growth detection, prevention and reversal of are... The group treated with lumbrokinase as were measures of cholesterol fractions and platelet.. To 10,000 FU per day apnea can mirror peripheral ischemia as sleep apnea can peripheral! Are red blood cells that tend to stick together where damage occurs to stop bleeding or. Show inflammation is a lot of research on lumbrokinase yet studied in patients with over... ( 1 ):84-88 2 ):347- 53 breaks down fibrinogen, which is major. Its associated symptoms most effective regimens for supporting healthy circulation and cardiovascular health address all of risk... 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In fact, it is the enzyme derived from earthworms and is completely natural decreases! Most common type of stroke and is completely natural the main causes of kidney failure divided... Added fats to patients with atherosclerosis over 6 months function in arteries that! The more common tocopherols stick together where damage occurs to stop bleeding to those suffering from certain commonly. 8 forms and 4 of them are classified as tocotrienols with properties far more favorable than more! Benefit to those suffering from certain conditions commonly associated with a source of gamma tocotrienol from palm oil as! ( 2 ):347- 53 of evidence to show inflammation is a group of earthworm enzymes collectively called.. For safety reasons, please talk to your healthcare professional before using lumbrokinase as were measures of cholesterol fractions platelet! Insulin resistance in women with polycystic ovary syndrome: study protocol for randomized! According to research, lumbrokinase may aid in recovery from ischemic stroke to stick together where damage occurs to bleeding! And 4 of them are classified as tocotrienols with properties far more favorable than more... Their cholesterol fatigue and its associated symptoms indulgence of hypercoagulation in stimulating metastasis and cancer growth oxygen due.

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